Reference(s)
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Category: Soft tissue sarcomas


Cancer Type: MFH/Fibrosarcoma

HGF/SF expression

Reference Number: 141
Fukuda, T. et al. Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. Pathol Int 48, 757-62 (1998).
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Met expression

Reference Number: 141
Fukuda, T. et al. Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. Pathol Int 48, 757-62 (1998).
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Reference Number: 144
Oda, Y., Naka, T., Takeshita, M., Iwamoto, Y. & Tsuneyoshi, M. Comparison of histological changes and changes in nm23 and c-MET expression between primary and metastatic sites in osteosarcoma: a clinicopathologic and immunohistochemical study. Hum Pathol 31, 709-16 (2000).
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Reference Number: 664
Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 68, 3350-60 (2008)
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Reference Number: 693
Schirosi L, Lantuejoul S, Cavazza A, Murer B, Yves Brichon P, Migaldi M, Sartori G, Sgambato A, Rossi G. Pleuro-pulmonary solitary fibrous tumors: a clinicopathologic, immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de Perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (alpha/beta), c-met, and EGFR. Am J Surg Pathol. 32, 1627-42 (2008)
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Reference Number: 856
Liang H, O'Reilly S, Liu Y, Abounader R, Laterra J, Maher VM, McCormick JJ. Sp1 regulates expression of MET, and ribozyme-induced down-regulation of MET in fibrosarcoma-derived human cells reduces or eliminates their tumorigenicity. Int J Oncol. 24, 1057-67 (2004)
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Reference Number: 918
Lee JC, Li CF, Fang FM, Wang JW, Jeng YM, Yu SC, Lin YT, Wu JM, Tsai JW, Li SH, Huang HY. Prognostic implication of MET overexpression in myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis. Mod Pathol. 23, 1379-92 (2010)
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Poor Prognosis

Mutation of Met

In vitro studies

Reference Number: 664
Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 68, 3350-60 (2008)
PubMed link      E-mail link

Animal models

Reference Number: 64
Jeffers, M. et al. The mutationally activated Met receptor mediates motility and metastasis. Proc Natl Acad Sci U S A 95, 14417-22 (1998).
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Reference Number: 152
Helou, K. et al. Amplification and overexpression of the hepatocyte growth factor receptor (HGFR/MET) in rat DMBA sarcomas. Oncogene 18, 3226-34. (1999).
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Reference Number: 153
Helou, K., Walentinsson, A., Kost-Alimova, M. & Levan, G. Hgfr/Met oncogene acts as target for gene amplification in DMBA-induced rat sarcomas: free chromatin fluorescence in situ hybridization analysis of amplicon arrays in homogeneously staining regions. Genes Chromosomes Cancer 30, 416-20. (2001).
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Reference Number: 154
Rong, S. et al. Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients. Cancer Res 55, 1963-70 (1995).
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Reference Number: 155
Webb, C. P. et al. Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene 17, 2019-25 (1998).
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Reference Number: 349
Sjoling A, Walentinsson A, Nordlander C, Karlsson A, Behboudi A, Samuelson E, Levan G, Rohme D. Assessment of allele dosage at polymorphic microsatellite loci displaying allelic imbalance in tumors by means of quantitative competitive-polymerase chain reaction. Cancer Genet Cytogenet157, 97-103 (2005)
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Therapeutic Development

Reference Number: 48
Morotti, A., Mila, S., Accornero, P., Tagliabue, E. & Ponzetto, C. K252a inhibits the oncogenic properties of Met, the HGF receptor. Oncogene 21, 4885-93 (2002).
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Reference Number: 918
Lee JC, Li CF, Fang FM, Wang JW, Jeng YM, Yu SC, Lin YT, Wu JM, Tsai JW, Li SH, Huang HY. Prognostic implication of MET overexpression in myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis. Mod Pathol. 23, 1379-92 (2010)
PubMed link      E-mail link

Reviews

Cancer Type: Leiomyosarcoma

HGF/SF expression

Reference Number: 138
Rong, S. et al. Met expression and sarcoma tumorigenicity. Cancer Res 53, 5355-60 (1993).
PubMed link      E-mail link

Reference Number: 312
Zhang YW, Su Y, Volpert OV, Vande Woude GF. Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc Natl Acad Sci USA 100, 12718-23 (2003)
PubMed link      E-mail link

Reference Number: 353
Jiao Y, Zhao P, Zhu J, Grabinski T, Feng Z, Guan X, Skinner RS, Gross MD, Hay RV, Tachibana H, Cao B. Construction of human naive Fab library and characterization of anti-met Fab fragment generated from the library. Mol Biotechnol. 31, 41-54 (2005)
PubMed link      E-mail link

Met expression

Reference Number: 114
Jeffers, M., Rong, S. & Vande Woude, G. F. Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol 16, 1115-25 (1996).
PubMed link      E-mail link

Reference Number: 138
Rong, S. et al. Met expression and sarcoma tumorigenicity. Cancer Res 53, 5355-60 (1993).
PubMed link      E-mail link

Reference Number: 353
Jiao Y, Zhao P, Zhu J, Grabinski T, Feng Z, Guan X, Skinner RS, Gross MD, Hay RV, Tachibana H, Cao B. Construction of human naive Fab library and characterization of anti-met Fab fragment generated from the library. Mol Biotechnol. 31, 41-54 (2005)
PubMed link      E-mail link

Reference Number: 354
Lee CC, Putnam AJ, Miranti CK, Gustafson M, Wang LM, Vande Woude GF, Gao CF. Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis. Oncogene 23, 5193-202 (2004)
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Reference Number: 355
Zhang YW, Wang LM, Jove R, Vande Woude GF. Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene 21, 217-26 (2002)
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Reference Number: 356
Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA 98, 247-52 (2001)
PubMed link      E-mail link

Reference Number: 640
Zhao P, Grabinski T, Gao C, Skinner RS, Giambernardi T, Su Y, Hudson E, Resau J, Gross M, Vande Woude GF, Hay R, Cao B. Identification of a met-binding peptide from a phage display library. Clin Cancer Res. 13, 6049-55 (2007)
PubMed link      E-mail link

Poor Prognosis

Reference Number: 312
Zhang YW, Su Y, Volpert OV, Vande Woude GF. Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc Natl Acad Sci USA 100, 12718-23 (2003)
PubMed link      E-mail link

Reference Number: 353
Jiao Y, Zhao P, Zhu J, Grabinski T, Feng Z, Guan X, Skinner RS, Gross MD, Hay RV, Tachibana H, Cao B. Construction of human naive Fab library and characterization of anti-met Fab fragment generated from the library. Mol Biotechnol. 31, 41-54 (2005)
PubMed link      E-mail link

Mutation of Met

In vitro studies

Reference Number: 138
Rong, S. et al. Met expression and sarcoma tumorigenicity. Cancer Res 53, 5355-60 (1993).
PubMed link      E-mail link

Reference Number: 312
Zhang YW, Su Y, Volpert OV, Vande Woude GF. Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc Natl Acad Sci USA 100, 12718-23 (2003)
PubMed link      E-mail link

Reference Number: 354
Lee CC, Putnam AJ, Miranti CK, Gustafson M, Wang LM, Vande Woude GF, Gao CF. Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis. Oncogene 23, 5193-202 (2004)
PubMed link      E-mail link

Reference Number: 356
Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA 98, 247-52 (2001)
PubMed link      E-mail link

Reference Number: 357
Castagnino P, Soriano JV, Montesano R, Bottaro DP. Induction of tissue inhibitor of metalloproteinases-3 is a delayed early cellular response to hepatocyte growth factor. Oncogene 17, 481-92 (1998)
PubMed link      E-mail link

Reference Number: 640
Zhao P, Grabinski T, Gao C, Skinner RS, Giambernardi T, Su Y, Hudson E, Resau J, Gross M, Vande Woude GF, Hay R, Cao B. Identification of a met-binding peptide from a phage display library. Clin Cancer Res. 13, 6049-55 (2007)
PubMed link      E-mail link

Animal models

Reference Number: 114
Jeffers, M., Rong, S. & Vande Woude, G. F. Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol 16, 1115-25 (1996).
PubMed link      E-mail link

Reference Number: 326
Zhang YW, Su Y, Lanning N, Gustafson M, Shinomiya N, Zhao P, Cao B, Tsarfaty G, Wang LM, Hay R, Vande Woude GF Enhanced growth of human met-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factor. Oncogene 24, 101-6 (2005)
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Reference Number: 345
Shinomiya N, Gao CF, Xie Q, Gustafson M, Waters DJ, Zhang YW, Vande Woude GF. RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival. Cancer Res64, 7962-70 (2004)
PubMed link      E-mail link

Reference Number: 353
Jiao Y, Zhao P, Zhu J, Grabinski T, Feng Z, Guan X, Skinner RS, Gross MD, Hay RV, Tachibana H, Cao B. Construction of human naive Fab library and characterization of anti-met Fab fragment generated from the library. Mol Biotechnol. 31, 41-54 (2005)
PubMed link      E-mail link

Therapeutic Development

Reference Number: 336
Xie Q, Gao CF, Shinomiya N, Sausville E, Hay R, Gustafson M, Shen Y, Wenkert D, Vande Woude GF. Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion. Oncogene 24, 3697-707 (2005)
PubMed link      E-mail link

Reference Number: 345
Shinomiya N, Gao CF, Xie Q, Gustafson M, Waters DJ, Zhang YW, Vande Woude GF. RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival. Cancer Res64, 7962-70 (2004)
PubMed link      E-mail link

Reference Number: 824
Gao CF, Xie Q, Zhang YW, Su Y, Zhao P, Cao B, Furge K, Sun J, Rex K, Osgood T, Coxon A, Burgess TL, Vande Woude GF. Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma. Mol Cancer Ther. 8, 2803-10 (2009)
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Reviews

Cancer Type: Kaposi's Sarcoma

HGF/SF expression

Reference Number: 156
Maier JA, Mariotti M, Albini A, Comi P, Prat M, Comogilio PM, Soria MR. Over-expression of hepatocyte growth factor in human Kaposi's sarcoma. Int J Cancer. 65, 168-72 (1996)
PubMed link      E-mail link

Reference Number: 157
Polverini, P. J. & Nickoloff, B. J. Role of scatter factor and the c-met protooncogene in the pathogenesis of AIDS-associated Kaposi's sarcoma. Adv Cancer Res 66, 235-53 (1995).
PubMed link      E-mail link

Reference Number: 158
Puig, L. et al. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol 26, 227-31 (1999).
PubMed link      E-mail link

Reference Number: 407
Bardelli C, Sala M, Cavallazzi U, Prat M. Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells. Biochem Biophys Res Commun. 334, 1172-9 (2005)
PubMed link      E-mail link

Reference Number: 408
Montaldo F, Maffe A, Morini M, Noonan D, Giordano S, Albini A, Prat M. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells. J Cell Physiol.  184, 246-54 (2000)
PubMed link      E-mail link

Reference Number: 409
Maier J, Mariotti M, Comoglio PM, Soria MR. Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells. Oncogene. 13, 1009-15 (1996)

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Reference Number: 494
Puig L, Fernández-Figueras MT, Penín RM, Esquius M, Alomar A, Ariza A. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol. 26, 227-31 (1999)
PubMed link      E-mail link

Met expression

Reference Number: 156
Maier JA, Mariotti M, Albini A, Comi P, Prat M, Comogilio PM, Soria MR. Over-expression of hepatocyte growth factor in human Kaposi's sarcoma. Int J Cancer. 65, 168-72 (1996)
PubMed link      E-mail link

Reference Number: 157
Polverini, P. J. & Nickoloff, B. J. Role of scatter factor and the c-met protooncogene in the pathogenesis of AIDS-associated Kaposi's sarcoma. Adv Cancer Res 66, 235-53 (1995).
PubMed link      E-mail link

Reference Number: 158
Puig, L. et al. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol 26, 227-31 (1999).
PubMed link      E-mail link

Reference Number: 407
Bardelli C, Sala M, Cavallazzi U, Prat M. Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells. Biochem Biophys Res Commun. 334, 1172-9 (2005)
PubMed link      E-mail link

Reference Number: 408
Montaldo F, Maffe A, Morini M, Noonan D, Giordano S, Albini A, Prat M. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells. J Cell Physiol.  184, 246-54 (2000)
PubMed link      E-mail link

Reference Number: 409
Maier J, Mariotti M, Comoglio PM, Soria MR. Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells. Oncogene. 13, 1009-15 (1996)

PubMed link      E-mail link

Reference Number: 494
Puig L, Fernández-Figueras MT, Penín RM, Esquius M, Alomar A, Ariza A. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol. 26, 227-31 (1999)
PubMed link      E-mail link

Poor Prognosis

Reference Number: 494
Puig L, Fernández-Figueras MT, Penín RM, Esquius M, Alomar A, Ariza A. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol. 26, 227-31 (1999)
PubMed link      E-mail link

Mutation of Met

In vitro studies

Reference Number: 407
Bardelli C, Sala M, Cavallazzi U, Prat M. Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells. Biochem Biophys Res Commun. 334, 1172-9 (2005)
PubMed link      E-mail link

Reference Number: 408
Montaldo F, Maffe A, Morini M, Noonan D, Giordano S, Albini A, Prat M. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells. J Cell Physiol.  184, 246-54 (2000)
PubMed link      E-mail link

Reference Number: 409
Maier J, Mariotti M, Comoglio PM, Soria MR. Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells. Oncogene. 13, 1009-15 (1996)

PubMed link      E-mail link

Reference Number: 600
Marchisone C, Del Grosso F, Masiello L, Prat M, Santi L, Noonan DM. Phenotypic alterations in Kaposi's sarcoma cells by antisense reduction of perlecan. Pathol Oncol Res. 6, 10-7 (2000)
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Reference Number: 976
Baldanzi G, Pietronave S, Locarno D, Merlin S, Porporato P, Chianale F, Filigheddu N, Cantelmo AR, Albini A, Graziani A, Prat M. Diacylglycerol kinases are essential for hepatocyte growth factor-dependent proliferation and motility of Kaposi's sarcoma cells. Cancer Sci. 102, 1329-36 (2011)
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Animal models

Reference Number: 159
Montaldo, F. et al. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells. J Cell Physiol 184, 246-54 (2000).
PubMed link      E-mail link

Therapeutic Development

Reviews