Reference(s)
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Cancer type: Endometrial


HGF/SF expression

Reference Number: 577
Yoshida S, Harada T, Iwabe T, Taniguchi F, Fujii A, Sakamoto Y, Yamauchi N, Shiota G, Terakawa N. Induction of hepatocyte growth factor in stromal cells by tumor-derived basic fibroblast growth factor enhances growth and invasion of endometrial cancer. J Clin Endocrinol Metab. 87, 2376-83 (2002)
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Reference Number: 578
Wagatsuma S, Konno R, Sato S, Yajima A. Tumor angiogenesis, hepatocyte growth factor, and c-Met expression in endometrial carcinoma. Cancer. 82, 520-30 (1998)
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Reference Number: 580
Bae-Jump V, Segreti EM, Vandermolen D, Kauma S. Hepatocyte growth factor (HGF) induces invasion of endometrial carcinoma cell lines in vitro. Gynecol Oncol. 73, 265-72 (1999)
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Reference Number: 831
Choi DS, Kim HJ, Yoon JH, Yoo SC, Jo H, Lee SY, Min CK, Ryu HS. Endometrial cancer invasion depends on cancer-derived tumor necrosis factor-alpha and stromal derived hepatocyte growth factor. Int J Cancer. 124, 2528-38 (2009)
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Reference Number: 1114
Yoshizawa Y, Yamada Y, Kanayama S, Shigetomi H, Kawaguchi R, Yoshida S, Nagai A, Furukawa N, Oi H, Kobayashi H. Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells. Oncol Rep. 26, 957-64 (2011)
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Reference Number: 1772
Li M, Xin X, Wu T, Hua T, Wang H, Wang H. Stromal cells of endometrial carcinoma promotes proliferation of epithelial cells through the HGF/c-Met/Akt signaling pathway. Tumour Biol. 36, 6239-48 (2015)
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Reference Number: 1870
Nakamura M, Ono YJ, Kanemura M, Tanaka T, Hayashi M, Terai Y, Ohmichi M. Hepatocyte growth factor secreted by ovarian cancer cells stimulates peritoneal implantation via the mesothelial-mesenchymal transition of the peritoneum. Gynecol Oncol. 139, 345-54 (2015)
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Met expression

Reference Number: 578
Wagatsuma S, Konno R, Sato S, Yajima A. Tumor angiogenesis, hepatocyte growth factor, and c-Met expression in endometrial carcinoma. Cancer. 82, 520-30 (1998)
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Reference Number: 579
Walentinsson A, Helou K, Wallenius V, Hedrich HJ, Szpirer C, Levan G. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Cancer Res. 61, 8263-73 (2001)
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Reference Number: 580
Bae-Jump V, Segreti EM, Vandermolen D, Kauma S. Hepatocyte growth factor (HGF) induces invasion of endometrial carcinoma cell lines in vitro. Gynecol Oncol. 73, 265-72 (1999)
PubMed link      E-mail link

Reference Number: 581
He Y, Peng Z, Pan X, Wang H, Ouyang Y. Expression and correlation of C-met and estrogen receptor in endometrial carcinomas. Sichuan Da Xue Xue Bao Yi Xue Ban. 34, 78-9 (2003)
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Reference Number: 582
O'Toole SA, Dunn E, Sheppard BL, Klocker H, Bektic J, Smyth P, Martin C, Sheils O, O'Leary JJ. Genome-wide analysis of deoxyribonucleic acid in endometrial cancer using comparative genomic hybridization microarrays. Int J Gynecol Cancer. 16, 834-42 (2006)
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Reference Number: 604
Samuelson E, Nordlander C, Levan G, Behboudi A. Amplification studies of MET and Cdk6 in a rat endometrial tumor model and their correlation to human type I endometrial carcinoma tumors. Adv Exp Med Biol. 617, 511-7 (2008)
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Reference Number: 1655
Thoury A, Descatoire V, Kotelevets L, Kannengiesser C, Bertrand G, Theou-Anton N, Frey C, Genestie C, Raymond E, Chastre E, Lehy T, Walker F. Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and high grade endometrial carcinomas in a cohort of consecutive women. Occurrence of PIK3CA and K-Ras mutations and microsatellite instability. Histol Histopathol. 29, 1455-66 (2014)
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Poor Prognosis

Mutation of Met

In vitro studies

Reference Number: 580
Bae-Jump V, Segreti EM, Vandermolen D, Kauma S. Hepatocyte growth factor (HGF) induces invasion of endometrial carcinoma cell lines in vitro. Gynecol Oncol. 73, 265-72 (1999)
PubMed link      E-mail link

Animal models

Reference Number: 604
Samuelson E, Nordlander C, Levan G, Behboudi A. Amplification studies of MET and Cdk6 in a rat endometrial tumor model and their correlation to human type I endometrial carcinoma tumors. Adv Exp Med Biol. 617, 511-7 (2008)
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Therapeutic Development

Reference Number: 715
Arena S, Pisacane A, Mazzone M, Comoglio PM, Bardelli A. Genetic targeting of the kinase activity of the Met receptor in cancer cells. Proc Natl Acad Sci U S A. 104, 11412-7 (2007)
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Reviews

Reference Number: 1726
Li M, Xin X, Wu T, Hua T, Wang H. HGF and c-Met in pathogenesis of endometrial carcinoma. Front Biosci (Landmark Ed). 20, 635-43 (2015)
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