Reference(s)
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Cancer type: Wilms' Tumor


HGF/SF expression

Reference Number: 216
Alami, J., Williams, B. R. & Yeger, H. Expression and localization of HGF and met in Wilms' tumours. J Pathol 196, 76-84. (2002).
PubMed link      E-mail link

Reference Number: 274
Higinbotham KG, Karavanova ID, Diwan BA, Perantoni AO. Deficient expression of mRNA for the putative inductive factor bone morphogenetic protein-7 in chemically initiated rat nephroblastomas. Mol Carcinog. 23, 53-61 (1998)
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Reference Number: 732
Vuononvirta R, Sebire NJ, Messahel B, Perusinghe N, Reis-Filho JS, Pritchard-Jones K, Vujanic GM, Jones C. Expression of hepatocyte growth factor and its receptor met in Wilms' tumors and nephrogenic rests reflects their roles in kidney development. Clin Cancer Res. 15, 2723-30 (2009)
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Met expression

Reference Number: 216
Alami, J., Williams, B. R. & Yeger, H. Expression and localization of HGF and met in Wilms' tumours. J Pathol 196, 76-84. (2002).
PubMed link      E-mail link

Reference Number: 375
Pinthus JH, Sheffer Y, Nagler A, Fridman E, Mor Y, Genina O, Pines M. Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression. J Urol. 174, 1527-31 (2005)
PubMed link      E-mail link

Reference Number: 732
Vuononvirta R, Sebire NJ, Messahel B, Perusinghe N, Reis-Filho JS, Pritchard-Jones K, Vujanic GM, Jones C. Expression of hepatocyte growth factor and its receptor met in Wilms' tumors and nephrogenic rests reflects their roles in kidney development. Clin Cancer Res. 15, 2723-30 (2009)
PubMed link      E-mail link

Poor Prognosis

Mutation of Met

In vitro studies

Animal models

Reference Number: 375
Pinthus JH, Sheffer Y, Nagler A, Fridman E, Mor Y, Genina O, Pines M. Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression. J Urol. 174, 1527-31 (2005)
PubMed link      E-mail link

Therapeutic Development

Reference Number: 375
Pinthus JH, Sheffer Y, Nagler A, Fridman E, Mor Y, Genina O, Pines M. Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression. J Urol. 174, 1527-31 (2005)
PubMed link      E-mail link

Reviews