Reference(s)
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Cancer type: Cervical


HGF/SF expression

Reference Number: 239
Walker F, Kermorgant S, Darai E, Madelenat P, Cremieux AC, Henin D, Lehy T. Hepatocyte growth factor and c-Met in cervical intraepithelial neoplasia: overexpression of proteins associated with oncogenic human papillomavirus and human immunodeficiency virus. Clin Cancer Res 9:273-84 (2003).
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Reference Number: 398
Tsai HW, Chow NH, Lin CP, Chan SH, Chou CY, Ho CL. The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. Hum Pathol. 37, 198-204. Epub 2005 Dec 20 (2006)
PubMed link      E-mail link

Reference Number: 467
Majka M, Drukala J, Lesko E, Wysoczynski M, Jenson AB, Ratajczak MZ. SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells. Folia Histochem Cytobiol. 44, 44155-64 (2006)
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Reference Number: 1232
Horn LC, Hommel N, Roschlau U, Bilek K, Hentschel B, Einenkel J. Peritumoral stromal remodeling, pattern of invasion and expression of c-met/HGF in advanced squamous cell carcinoma of the cervix uteri, FIGO stages III and IV. Eur J Obstet Gynecol Reprod Biol. 163, 76-80 (2012)
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Reference Number: 1592
Zhang Y, Wu JZ, Yang YQ, Ma R, Zhang JY, Feng JF Expression of growth regulated oncogene 1, hepatocyte growth factor, platelet derived growth factor AA and soluble E selectin and their association with high risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix. Mol Med Rep. 10, 1013-24 (2014)
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Met expression

Reference Number: 29
Baykal, C., Ayhan, A., Al, A. & Yuce, K. Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix carcinomas. Gynecol Oncol 88, 123-9. (2003).
PubMed link      E-mail link

Reference Number: 238
Hudelist G, Czerwenka K, Singer C, Pischinger K, Kubista E, Manavi M. cDNA array analysis of cytobrush-collected normal and malignant cervical epithelial cells: a feasibility study. Cancer Genet Cytogenet. 158, 35-42 (2005)
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Reference Number: 239
Walker F, Kermorgant S, Darai E, Madelenat P, Cremieux AC, Henin D, Lehy T. Hepatocyte growth factor and c-Met in cervical intraepithelial neoplasia: overexpression of proteins associated with oncogenic human papillomavirus and human immunodeficiency virus. Clin Cancer Res 9:273-84 (2003).
PubMed link      E-mail link

Reference Number: 398
Tsai HW, Chow NH, Lin CP, Chan SH, Chou CY, Ho CL. The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. Hum Pathol. 37, 198-204. Epub 2005 Dec 20 (2006)
PubMed link      E-mail link

Reference Number: 466
Leo C, Horn LC, Einenkel J, Hentschel B, Hockel M. Tumor hypoxia and expression of c-met in cervical cancer. Gynecol Oncol. 104, 181-5 (2007)
PubMed link      E-mail link

Reference Number: 624
Lee WY, Huang SC, Hsu KF, Tzeng CC, Shen WL. Roles for hypoxia-regulated genes during cervical carcinogenesis: somatic evolution during the hypoxia-glycolysis-acidosis sequence. Gynecol Oncol. 108, 377-84 (2008)
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Reference Number: 1179
Chen TC, Hung YC, Lin TY, Chang HW, Chiang IP, Chen YY, Chow KC. Human papillomavirus infection and expression of ATPase family AAA domain containing 3A, a novel anti-autophagy factor, in uterine cervical cancer. Int J Mol Med. 28, 689-96 (2011)
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Reference Number: 1232
Horn LC, Hommel N, Roschlau U, Bilek K, Hentschel B, Einenkel J. Peritumoral stromal remodeling, pattern of invasion and expression of c-met/HGF in advanced squamous cell carcinoma of the cervix uteri, FIGO stages III and IV. Eur J Obstet Gynecol Reprod Biol. 163, 76-80 (2012)
PubMed link      E-mail link

Reference Number: 1269
Comunoglu C, Boynukalin K, Ugur MG, Al R, Kuzey GM, Baykal C. Overexpression of c-Met in cervical intraepithelial neoplasia. Eur J Gynaecol Oncol. 33, 625-8 (2012)
PubMed link      E-mail link

Reference Number: 1365
Kim BW1, Cho H, Chung JY, Conway C, Ylaya K, Kim JH, Hewitt SM. Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry. J Transl Med. 11, 185 (2013)
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Reference Number: 1762
Zhuang XP, Jin WW, Teng XD, Yuan ZZ, Lin QQ, Xu ST. c-Met and RON expression levels in endometrial adenocarcinoma tissue and their relationship with prognosis. Eur J Gynaecol Oncol. 36, 255-9 (2015)
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Reference Number: 1838
Miekus K, Pawlowska M, Sekula M, Drabik G, Madeja Z, Adamek D, Majka M MET receptor is a potential therapeutic target in high grade cervical cancer. Oncotarget. 6, 10086-101 (2015)
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Poor Prognosis

Reference Number: 29
Baykal, C., Ayhan, A., Al, A. & Yuce, K. Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix carcinomas. Gynecol Oncol 88, 123-9. (2003).
PubMed link      E-mail link

Reference Number: 398
Tsai HW, Chow NH, Lin CP, Chan SH, Chou CY, Ho CL. The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. Hum Pathol. 37, 198-204. Epub 2005 Dec 20 (2006)
PubMed link      E-mail link

Reference Number: 466
Leo C, Horn LC, Einenkel J, Hentschel B, Hockel M. Tumor hypoxia and expression of c-met in cervical cancer. Gynecol Oncol. 104, 181-5 (2007)
PubMed link      E-mail link

Reference Number: 1365
Kim BW1, Cho H, Chung JY, Conway C, Ylaya K, Kim JH, Hewitt SM. Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry. J Transl Med. 11, 185 (2013)
PubMed link      E-mail link

Mutation of Met

In vitro studies

Reference Number: 467
Majka M, Drukala J, Lesko E, Wysoczynski M, Jenson AB, Ratajczak MZ. SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells. Folia Histochem Cytobiol. 44, 44155-64 (2006)
PubMed link      E-mail link

Animal models

Reference Number: 1558
Chen XP, Ren XP, Lan JY, Chen YG, Shen ZJ. Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice. Mol Biol Rep. 41, 1247-56 (2014)
PubMed link      E-mail link

Therapeutic Development

Reference Number: 398
Tsai HW, Chow NH, Lin CP, Chan SH, Chou CY, Ho CL. The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. Hum Pathol. 37, 198-204. Epub 2005 Dec 20 (2006)
PubMed link      E-mail link

Reference Number: 1316
Kina S, Phonaphonh T, Liang F, Kuang H, Arasaki A, Arakaki K, Nakasone T, Sunakawa H. PDGF a receptor is a mediator for Cisplatin-induced Met expression. Eur J Pharmacol. 699, 227-32 (2013)
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Reviews