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Cancer type: Acute Myelogenous Leukemia

HGF/SF expression

Reference Number: 181
Hino, M. et al. Hepatocyte growth factor levels in bone marrow plasma of patients with leukaemia and its gene expression in leukaemic blast cells. Br J Cancer 73, 119-23. (1996).
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Reference Number: 182
Hjorth-Hansen, H. et al. Elevated serum concentrations of hepatocyte growth factor in acute myelocytic leukaemia. Eur J Haematol 62, 129-34 (1999).
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Reference Number: 183
Verstovsek, S. et al. Plasma hepatocyte growth factor is a prognostic factor in patients with acute myeloid leukemia but not in patients with myelodysplastic syndrome. Leukemia 15, 1165-70. (2001).
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Met expression

Reference Number: 1735
McGee SF, Kornblau SM, Qiu Y, Look AT, Zhang N, Yoo SY, Coombes KR, Kentsis A Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia. Leukemia. 29, 1218-21 (2015)
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Poor Prognosis

Mutation of Met

In vitro studies

Reference Number: 184
Weimar, I. S. et al. Hepatocyte growth factor/scatter factor (HGF/SF) affects proliferation and migration of myeloid leukemic cells. Leukemia 12, 1195-203 (1998).
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Animal models

Therapeutic Development