Reference(s)
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Cancer type: Kaposi's Sarcoma


HGF/SF expression

Reference Number: 156
Maier JA, Mariotti M, Albini A, Comi P, Prat M, Comogilio PM, Soria MR. Over-expression of hepatocyte growth factor in human Kaposi's sarcoma. Int J Cancer. 65, 168-72 (1996)
PubMed link      E-mail link

Reference Number: 157
Polverini, P. J. & Nickoloff, B. J. Role of scatter factor and the c-met protooncogene in the pathogenesis of AIDS-associated Kaposi's sarcoma. Adv Cancer Res 66, 235-53 (1995).
PubMed link      E-mail link

Reference Number: 158
Puig, L. et al. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol 26, 227-31 (1999).
PubMed link      E-mail link

Reference Number: 407
Bardelli C, Sala M, Cavallazzi U, Prat M. Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells. Biochem Biophys Res Commun. 334, 1172-9 (2005)
PubMed link      E-mail link

Reference Number: 408
Montaldo F, Maffe A, Morini M, Noonan D, Giordano S, Albini A, Prat M. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells. J Cell Physiol.  184, 246-54 (2000)
PubMed link      E-mail link

Reference Number: 409
Maier J, Mariotti M, Comoglio PM, Soria MR. Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells. Oncogene. 13, 1009-15 (1996)

PubMed link      E-mail link

Reference Number: 494
Puig L, Fernández-Figueras MT, Penín RM, Esquius M, Alomar A, Ariza A. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol. 26, 227-31 (1999)
PubMed link      E-mail link

Met expression

Reference Number: 156
Maier JA, Mariotti M, Albini A, Comi P, Prat M, Comogilio PM, Soria MR. Over-expression of hepatocyte growth factor in human Kaposi's sarcoma. Int J Cancer. 65, 168-72 (1996)
PubMed link      E-mail link

Reference Number: 157
Polverini, P. J. & Nickoloff, B. J. Role of scatter factor and the c-met protooncogene in the pathogenesis of AIDS-associated Kaposi's sarcoma. Adv Cancer Res 66, 235-53 (1995).
PubMed link      E-mail link

Reference Number: 158
Puig, L. et al. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol 26, 227-31 (1999).
PubMed link      E-mail link

Reference Number: 407
Bardelli C, Sala M, Cavallazzi U, Prat M. Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells. Biochem Biophys Res Commun. 334, 1172-9 (2005)
PubMed link      E-mail link

Reference Number: 408
Montaldo F, Maffe A, Morini M, Noonan D, Giordano S, Albini A, Prat M. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells. J Cell Physiol.  184, 246-54 (2000)
PubMed link      E-mail link

Reference Number: 409
Maier J, Mariotti M, Comoglio PM, Soria MR. Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells. Oncogene. 13, 1009-15 (1996)

PubMed link      E-mail link

Reference Number: 494
Puig L, Fernández-Figueras MT, Penín RM, Esquius M, Alomar A, Ariza A. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol. 26, 227-31 (1999)
PubMed link      E-mail link

Poor Prognosis

Reference Number: 494
Puig L, Fernández-Figueras MT, Penín RM, Esquius M, Alomar A, Ariza A. Differential expression of c-Met in Kaposi's sarcoma according to progression stage and HIV infection status. J Cutan Pathol. 26, 227-31 (1999)
PubMed link      E-mail link

Mutation of Met

In vitro studies

Reference Number: 407
Bardelli C, Sala M, Cavallazzi U, Prat M. Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells. Biochem Biophys Res Commun. 334, 1172-9 (2005)
PubMed link      E-mail link

Reference Number: 408
Montaldo F, Maffe A, Morini M, Noonan D, Giordano S, Albini A, Prat M. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells. J Cell Physiol.  184, 246-54 (2000)
PubMed link      E-mail link

Reference Number: 409
Maier J, Mariotti M, Comoglio PM, Soria MR. Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells. Oncogene. 13, 1009-15 (1996)

PubMed link      E-mail link

Reference Number: 600
Marchisone C, Del Grosso F, Masiello L, Prat M, Santi L, Noonan DM. Phenotypic alterations in Kaposi's sarcoma cells by antisense reduction of perlecan. Pathol Oncol Res. 6, 10-7 (2000)
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Reference Number: 976
Baldanzi G, Pietronave S, Locarno D, Merlin S, Porporato P, Chianale F, Filigheddu N, Cantelmo AR, Albini A, Graziani A, Prat M. Diacylglycerol kinases are essential for hepatocyte growth factor-dependent proliferation and motility of Kaposi's sarcoma cells. Cancer Sci. 102, 1329-36 (2011)
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Animal models

Reference Number: 159
Montaldo, F. et al. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells. J Cell Physiol 184, 246-54 (2000).
PubMed link      E-mail link

Therapeutic Development

Reviews