Reference(s)
Click here to return to the Reference Table

Cancer type: Nasopharyngeal


HGF/SF expression

Reference Number: 104
Qian, C. N. et al. Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma. Cancer Res 62, 589-96 (2002).
PubMed link      E-mail link

Reference Number: 596
Li Z, Lin SX, Liang HZ, He JH. [Expression of hepatocyte growth factor/c-Met system in nasopharyngeal carcinoma and its biological significance]
[Article in Chinese] Zhonghua Bing Li Xue Za Zhi. 34, 75-9 (2005)

PubMed link      E-mail link

Reference Number: 709
Lim YC, Park HY, Hwang HS, Kang SU, Pyun JH, Lee MH, Choi EC, Kim CH. (-)-Epigallocatechin-3-gallate (EGCG) inhibits HGF-induced invasion and metastasis in hypopharyngeal carcinoma cells. Cancer Lett. 271, 140-52 (2008) Epub 2008 Jul 15
PubMed link      E-mail link

Reference Number: 795
Xie LQ, Bian LJ, Li Z, Li Y, Liang YJ. Co-elevated expression of hepatocyte growth factor and Interleukin-8 contributes to poor prognosis of patients with primary nasopharyngeal carcinoma. Oncol Rep. 23, 141-50 (2010)
PubMed link      E-mail link

Reference Number: 796
Li-juan B, Bing L, Zhi L, Yang L, Ying-jie L. Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression. Pathol Res Pract. 205, 828-37 (2009)
PubMed link      E-mail link

Reference Number: 801
Xie LQ, Bian LJ, Li Z, Li Y, Li ZX, Li B. Altered expression of E-cadherin by hepatocyte growth factor and effect on the prognosis of nasopharyngeal carcinoma. Ann Surg Oncol. 17, 1927-36 (2010)
PubMed link      E-mail link

Met expression

Reference Number: 104
Qian, C. N. et al. Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma. Cancer Res 62, 589-96 (2002).
PubMed link      E-mail link

Reference Number: 105
Horikawa, T. et al. Induction of c-Met proto-oncogene by Epstein-Barr virus latent membrane protein-1 and the correlation with cervical lymph node metastasis of nasopharyngeal carcinoma. Am J Pathol 159, 27-33. (2001).
PubMed link      E-mail link

Reference Number: 447
Toda S, Yamada S, Aoki S, Inokuchi A, Sugihara H. Air-liquid interface promotes invasive growth of laryngeal squamous cell carcinoma with or without hypoxia. Biochem Biophys Res Commun. 326, 866-72 (2005)
PubMed link      E-mail link

Reference Number: 596
Li Z, Lin SX, Liang HZ, He JH. [Expression of hepatocyte growth factor/c-Met system in nasopharyngeal carcinoma and its biological significance]
[Article in Chinese] Zhonghua Bing Li Xue Za Zhi. 34, 75-9 (2005)

PubMed link      E-mail link

Reference Number: 699
Zhou HY, Wan KF, Ip CK, Wong CK, Mak NK, Lo KW, Wong AS. Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK. FEBS Lett. 582, 3415-22 (2008) Epub 2008 Sep 18
PubMed link      E-mail link

Reference Number: 1115
Kim YJ, Go H, Wu HG, Jeon YK, Park SW, Lee SH. Immunohistochemical study identifying prognostic biomolecular markers in nasopharyngeal carcinoma treated by radiotherapy. Head Neck. 33, 1458-66 (2011)
PubMed link      E-mail link

Reference Number: 1116
Li Y, Zhang S, Tang Z, Chen J, Kong W. Silencing of c-Met by RNA interference inhibits the survival, proliferation, and invasion of nasopharyngeal carcinoma cells. Tumour Biol. 32, 1217-24 (2011)
PubMed link      E-mail link

Reference Number: 1730
Li YQ, Ren XY, He QM, Xu YF, Tang XR, Sun Y, Zeng MS, Kang TB, Liu N, Ma J MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET. Cell Death Dis. 6, e1618 (2015)
PubMed link      E-mail link

Reference Number: 1797
Li Y, Li W, He Q, Xu Y, Ren X, Tang X, Wen X, Yang X, Sun Y, Zeng J, Yun J, Liu N, Ma J. Prognostic value of MET protein overexpression and gene amplification in locoregionally advanced nasopharyngeal carcinoma. Oncotarget. 6, 13309-19 (2015)
PubMed link      E-mail link

Reference Number: 1841
Li Y, Li W, He Q, Xu Y, Ren X, Tang X, Wen X, Yang X, Sun Y, Zeng J, Yun J, Liu N, Ma J. Prognostic value of MET protein overexpression and gene amplification in locoregionally advanced nasopharyngeal carcinoma. Oncotarget. 6, 13309-19 (2015)
PubMed link      E-mail link

Poor Prognosis

Reference Number: 104
Qian, C. N. et al. Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma. Cancer Res 62, 589-96 (2002).
PubMed link      E-mail link

Reference Number: 795
Xie LQ, Bian LJ, Li Z, Li Y, Liang YJ. Co-elevated expression of hepatocyte growth factor and Interleukin-8 contributes to poor prognosis of patients with primary nasopharyngeal carcinoma. Oncol Rep. 23, 141-50 (2010)
PubMed link      E-mail link

Reference Number: 796
Li-juan B, Bing L, Zhi L, Yang L, Ying-jie L. Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression. Pathol Res Pract. 205, 828-37 (2009)
PubMed link      E-mail link

Reference Number: 1841
Li Y, Li W, He Q, Xu Y, Ren X, Tang X, Wen X, Yang X, Sun Y, Zeng J, Yun J, Liu N, Ma J. Prognostic value of MET protein overexpression and gene amplification in locoregionally advanced nasopharyngeal carcinoma. Oncotarget. 6, 13309-19 (2015)
PubMed link      E-mail link

Mutation of Met

In vitro studies

Reference Number: 104
Qian, C. N. et al. Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma. Cancer Res 62, 589-96 (2002).
PubMed link      E-mail link

Reference Number: 105
Horikawa, T. et al. Induction of c-Met proto-oncogene by Epstein-Barr virus latent membrane protein-1 and the correlation with cervical lymph node metastasis of nasopharyngeal carcinoma. Am J Pathol 159, 27-33. (2001).
PubMed link      E-mail link

Reference Number: 699
Zhou HY, Wan KF, Ip CK, Wong CK, Mak NK, Lo KW, Wong AS. Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK. FEBS Lett. 582, 3415-22 (2008) Epub 2008 Sep 18
PubMed link      E-mail link

Reference Number: 795
Xie LQ, Bian LJ, Li Z, Li Y, Liang YJ. Co-elevated expression of hepatocyte growth factor and Interleukin-8 contributes to poor prognosis of patients with primary nasopharyngeal carcinoma. Oncol Rep. 23, 141-50 (2010)
PubMed link      E-mail link

Reference Number: 796
Li-juan B, Bing L, Zhi L, Yang L, Ying-jie L. Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression. Pathol Res Pract. 205, 828-37 (2009)
PubMed link      E-mail link

Reference Number: 967
Lui VW, Wong EY, Ho K, Ng PK, Lau CP, Tsui SK, Tsang CM, Tsao SW, Cheng SH, Ng MH, Ng YK, Lam EK, Hong B, Lo KW, Mok TS, Chan AT, Mills GB. Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death. Oncogene. 30, 1127-34 (2011)
PubMed link      E-mail link

Animal models

Therapeutic Development

Reference Number: 967
Lui VW, Wong EY, Ho K, Ng PK, Lau CP, Tsui SK, Tsang CM, Tsao SW, Cheng SH, Ng MH, Ng YK, Lam EK, Hong B, Lo KW, Mok TS, Chan AT, Mills GB. Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death. Oncogene. 30, 1127-34 (2011)
PubMed link      E-mail link

Reference Number: 1163
Lau PC, Wong EY. Targeting MET by tyrosine kinase inhibitor suppresses growth and invasion of nasopharyngeal carcinoma cell lines. Pathol Oncol Res. 18, 357-63 (2012)
PubMed link      E-mail link

Reference Number: 1448
Liu T1, Li Q2, Sun Q1, Zhang Y1, Yang H1, Wang R1, Chen L1, Wang W3. MET inhibitor PHA-665752 suppresses the hepatocyte growth factor-induced cell proliferation and radioresistance in nasopharyngeal carcinoma cells. Biochem Biophys Res Commun. 449, 49-54 (2014)
PubMed link      E-mail link

Reference Number: 1730
Li YQ, Ren XY, He QM, Xu YF, Tang XR, Sun Y, Zeng MS, Kang TB, Liu N, Ma J MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET. Cell Death Dis. 6, e1618 (2015)
PubMed link      E-mail link

Reviews